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覚醒マウス脳表における神経活動および脳血流変化の同時計測システムの構築
https://repo.qst.go.jp/records/65385
https://repo.qst.go.jp/records/65385e556cc02-cf23-4a2c-a701-50b43891236e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-12-11 | |||||
| タイトル | ||||||
| タイトル | 覚醒マウス脳表における神経活動および脳血流変化の同時計測システムの構築 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
田桑, 弘之
× 田桑, 弘之× 西野, 明日香× 川口, 拓之× 正本, 和人× 松浦, 哲也× 菅野, 巖× 伊藤, 浩× 田桑 弘之× 西野 明日香× 川口 拓之× 正本 和人× 松浦 哲也× 菅野 巖× 伊藤 浩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate the mechanism of hemodynamic response to neural activation, we developed two simultaneous measurement systems in awake mice. One is a simultaneous measurement method of cerebral blood flow (CBF) and cerebral blood volume (CBV) and the other is that of a membrane potential changes in neuron and CBV. Change in CBF and CBV during neural activation were simultaneously measured in somatosensory cortex using laser speckle flowmetry and intrinsic optical signal (IOS) imaging, respectively. Response curves of CBF and CBV during neural activation were good agreement with our previous studies using laser–Doppler flowmetry and positron emission tomography. The membrane potential changes and CBV during neural activation were simultaneously measured using voltage sensitive dye (VSD) and IOS imaging, respectively. Images of neural activation and CBV were relatively stable and well localized at somatosensory cortex. These findings indicated that our method was useful to investigate mechanism of neurovascular coupling and brain disorder. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | レーザー学会第４５２回研究会「ニューロフォトニクス」 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-11-29 | |||||
| 日付タイプ | Issued | |||||
