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糖鎖の重粒子線感受性に関する基礎研究
https://repo.qst.go.jp/records/65266
https://repo.qst.go.jp/records/65266ff973f53-02fd-4e42-b49c-83b27e10e5de
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-13 | |||||
| タイトル | ||||||
| タイトル | 糖鎖の重粒子線感受性に関する基礎研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
中山, 文明
× 中山, 文明× 梅田, 禎子× 今井, 高志× 中山 文明× 梅田 禎子× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study focuses on clarifying the contribution of sulfation to C-ion-induced apoptosis in human Burkitt's lymphoma cell lines, using 3'-phosphoadenosine 5'-phosphosulfate transporters (PAPSTs). Overexpression of PAPST1 or PAPST2 reduced C-ion-induced apoptosis in Namalwa cells, whereas the repression of PAPST1 expression enhanced apoptosis. FACS analysis showed that all three Burkitt's lymphoma cell lines expressed keratan sulfate (KS), although the expression levels of heparan sulfate (HS) and chondroitin sulfate (CS) were very low. Inhibition of PAPST slightly decreased keratan sulfate (KS) expression, so that depletion of KS significantly increased radiation-induced apoptosis. In addition, the repression of all three N-acetylglucosamine-6-O-sulfotransferases (CHST2, CHST6, and CHST7) increased C-ion-induced apoptosis. In contrast, PAPST1 expression promoted the phosphorylation of p38 MAPK and Akt in X-ray-irradiated Namalwa cells. These findings suggest that 6-O-sulfation of GlcNAc residues in KS reduces C-ion-induced apoptosis of human Burkitt's lymphoma cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成24年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-04-23 | |||||
| 日付タイプ | Issued | |||||
