@misc{oai:repo.qst.go.jp:00065266,
 author = {中山, 文明 and 梅田, 禎子 and 今井, 高志 and 中山 文明 and 梅田 禎子 and 今井 高志},
 month = {Apr},
 note = {This study focuses on clarifying the contribution of sulfation to C-ion-induced apoptosis in human Burkitt's lymphoma cell lines, using 3'-phosphoadenosine 5'-phosphosulfate transporters (PAPSTs). Overexpression of PAPST1 or PAPST2 reduced C-ion-induced apoptosis in Namalwa cells, whereas the repression of PAPST1 expression enhanced apoptosis. FACS analysis showed that all three Burkitt's lymphoma cell lines expressed keratan sulfate (KS), although the expression levels of heparan sulfate (HS) and chondroitin sulfate (CS) were very low. Inhibition of PAPST slightly decreased keratan sulfate (KS) expression, so that depletion of KS significantly increased radiation-induced apoptosis. In addition, the repression of all three N-acetylglucosamine-6-O-sulfotransferases (CHST2, CHST6, and CHST7) increased C-ion-induced apoptosis. In contrast, PAPST1 expression promoted the phosphorylation of p38 MAPK and Akt in X-ray-irradiated Namalwa cells. These findings suggest that 6-O-sulfation of GlcNAc residues in KS reduces C-ion-induced apoptosis of human Burkitt's lymphoma cells., 平成24年度HIMAC共同利用研究成果発表会},
 title = {糖鎖の重粒子線感受性に関する基礎研究},
 year = {2013}
}