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Hsp90阻害剤PU-H71と炭素線照射の併用による癌抑制効果
https://repo.qst.go.jp/records/65176
https://repo.qst.go.jp/records/651766e8dc24a-7253-4a1a-8423-43f0de074435
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-08 | |||||
| タイトル | ||||||
| タイトル | Hsp90阻害剤PU-H71と炭素線照射の併用による癌抑制効果 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
岡安, 隆一
× 岡安, 隆一× 正岡, 綾× 李, 惠子× 平川, 博一× 松本, 孔貴× 藤森, 亮× 岡安 隆一× 正岡 綾× 李 惠子× 平川 博一× 松本 孔貴× 藤森 亮 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have been studying the combined effect of Hsp90 inhibitors and carbon ion irradiation. Our recent investigation indicated that 17AAG, an effective Hsp90 inhibitor derived from geldanamycin, clearly gave radiosensitizing effect in SQ5 human lung tumor cells irradiated with carbon ions. In this study, another Hsp90 inhibitor PU-H71 was examined for the combined effect with carbon ions. Our data indicated that pretreatment of 1 uM PU-H71 clearly showed an enhanced radio-sensitization in SQ5 cells irradiated with carbon ions (290 MeV/n, ~ 50 keV/um at spread-out Bragg peak). Our preliminary in vivo mouse xenogratft study also revealed an advantage in tumor growth control in the combined treatment of PU-H71 (40mg/kg) and carbon ion irradiation when compared to carbon irradiation alone. The cause of this radio-sensitizing effect by PU-H71 is under investigation; however, an effect on Rad 51, a DNA Double strand break (DSB) repair protein, was clearly observed in tumor cells treated with PU-H71 and carbon ion irradiation. These results propose another good candidate for the combined radiation treatment with carbon ions. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第72回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-10-05 | |||||
| 日付タイプ | Issued | |||||
