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Brain acetylcholinesterase changes in dementia with Lewy Bodies and Parkinson's disease with dementia demonstrated by PET
https://repo.qst.go.jp/records/65129
https://repo.qst.go.jp/records/651296cbcd7b9-df70-4983-bfbf-94a83e90eafd
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-11 | |||||
| タイトル | ||||||
| タイトル | Brain acetylcholinesterase changes in dementia with Lewy Bodies and Parkinson's disease with dementia demonstrated by PET | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shimada, Hitoshi
× Shimada, Hitoshi× Hirano, Shigeki× Shinoto, Hitoshi× Asahina, Masato× Sato, Koichi× Tanaka, Noriko× Ota, Tsuneyoshi× Fukushi, Kiyoshi× Suhara, Tetsuya× Hattori, Takamichi× Irie, Toshiaki× 島田 斉× 平野 成樹× 篠遠 仁× 佐藤 康一× 田中 典子× 黄田 常嘉× 福士 清× 須原 哲也× 入江 俊章 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: To investigate alterations of brain cholinergic function in patients with Dementia with Lewy Bodies (DLB) and Parkinson's Disease with Dementia (PDD) by measurements of brain acethylcholinesterase (AChE) activity in vivo. Methods: Participants were 10 patients with DLB (mean age: 75+/-4 years; male/female: 5/5; MMSE: 19+/-5), 10 patients with PDD (mean age: 75+/-4 years; male/female: 4/6; MMSE: 18+/-6), 9 patients with PD (mean age: 66+/-6 years; male/female: 6/3; MMSE: 28+/-2) and age-matched 27 healthy controls (mean age: 64+-10years; male/female: 14/13; MMSE: 29+-1). We performed N-[11C]-methyl-4-piperidyl acetate (MP4A) PET scan for 40 minutes with arterial blood sampling, and the regional brain AChE activities were estimated in the three-compartment model. Brain AChE activities were compared between DLB group and healthy control group by voxel-based analysis using the two sample t-test in statistical parametric mapping 2 (SPM), and .mean AChE activities of the cerebral cortex were also compared. Same statistical analyses were performed between PDD and controls, and between PD and controls. Results: The mean AChE activity of the cerebral cortex was significantly lower in the DLB(%reduction:29.4%) and PDD(-24.4%) groups compared with the PD(-11.5%) group and the healthy control group(ANOVA, p<0.01:DLBvsPD, DLBvsNC, PDDvsNC, p<0.05:PDDvsPD respectively). The SPM showed that regional AChE activities were significantly lower in almost all cortical areas in the DLB and PDD groups (FWE corrected p<0.01). The distribution and the degree of the reduction of AChE activities in DLB patients was similar to that in PDD patients. Conclusions: Severe cholinergic impairments were shown in patients with DLB and PDD compared with PD patients, and no remarkable differences were shown in the brain cholinergic decline between DLB and PDD patients. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 17th WFN World Congress on Parkinson's disease and Related Disorders | |||||
| 発表年月日 | ||||||
| 日付 | 2007-12-13 | |||||
| 日付タイプ | Issued | |||||
