@misc{oai:repo.qst.go.jp:00065129,
 author = {Shimada, Hitoshi and Hirano, Shigeki and Shinoto, Hitoshi and Asahina, Masato and Sato, Koichi and Tanaka, Noriko and Ota, Tsuneyoshi and Fukushi, Kiyoshi and Suhara, Tetsuya and Hattori, Takamichi and Irie, Toshiaki and 島田 斉 and 平野 成樹 and 篠遠 仁 and 佐藤 康一 and 田中 典子 and 黄田 常嘉 and 福士 清 and 須原 哲也 and 入江 俊章},
 month = {Dec},
 note = {Objectives: To investigate alterations of brain cholinergic function in patients with Dementia with Lewy Bodies (DLB) and Parkinson's Disease with Dementia (PDD) by measurements of brain acethylcholinesterase (AChE) activity in vivo. Methods: Participants were 10 patients with DLB (mean age: 75+/-4 years; male/female: 5/5; MMSE: 19+/-5), 10 patients with PDD (mean age: 75+/-4 years; male/female: 4/6; MMSE: 18+/-6), 9 patients with PD (mean age: 66+/-6 years; male/female: 6/3; MMSE: 28+/-2) and age-matched 27 healthy controls (mean age: 64+-10years; male/female: 14/13; MMSE: 29+-1). We performed N-[11C]-methyl-4-piperidyl acetate (MP4A) PET scan for 40 minutes with arterial blood sampling, and the regional brain AChE activities were estimated in the three-compartment model. Brain AChE activities were compared between DLB group and healthy control group by voxel-based analysis using the two sample t-test in statistical parametric mapping 2 (SPM), and .mean AChE activities of the cerebral cortex were also compared. Same statistical analyses were performed between PDD and controls, and between PD and controls. Results: The mean AChE activity of the cerebral cortex was significantly lower in the DLB(%reduction:29.4%) and PDD(-24.4%) groups compared with the PD(-11.5%) group and the healthy control group(ANOVA, p<0.01:DLBvsPD, DLBvsNC, PDDvsNC, p<0.05:PDDvsPD respectively). The SPM showed that regional AChE activities were significantly lower in almost all cortical areas in the DLB and PDD groups (FWE corrected p<0.01). The distribution and the degree of the reduction of AChE activities in DLB patients was similar to that in PDD patients. Conclusions: Severe cholinergic impairments were shown in patients with DLB and PDD compared with PD patients, and no remarkable differences were shown in the brain cholinergic decline between DLB and PDD patients., 17th WFN World Congress on Parkinson's disease and Related Disorders},
 title = {Brain acetylcholinesterase changes in dementia with Lewy Bodies and Parkinson's disease with dementia demonstrated by PET},
 year = {2007}
}