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Hsp90 inhibitor is a good candidate for effective combination therapy with carbon ions
https://repo.qst.go.jp/records/65014
https://repo.qst.go.jp/records/6501446af0ed6-cac3-4120-b164-6644031f3e82
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-05-24 | |||||
| タイトル | ||||||
| タイトル | Hsp90 inhibitor is a good candidate for effective combination therapy with carbon ions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okayasu, Ryuichi
× Okayasu, Ryuichi× Hirakawa, Hirokazu× Masaoka, Aya× Noguchi, Miho× Hirayama, Ryoichi× Li, Huizi× Matsumoto, Yoshitaka× Fujimori, Akira× 岡安 隆一× 平川 博一× 正岡 綾× 平山 亮一× 李 惠子× 松本 孔貴× 藤森 亮 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have shown an Hsp90 inhibitor 17AAG can be an effective radio-sensitizer with X-rays for certain human tumor cells, while normal cells were not sensitized by this drug. The underlying mechanism for this effect was shown to be inhibition of DNA double strand breaks (DSBs) by 17AAG. In vivo mouse xenograft study also showed a better tumor control with the pretreatment of this drug when compared with X-ray treatment alone. We have extended the combination study to carbon ion irradiation in vitro and in vivo. Our data indicate that cancer cells are also controlled better with the combination of 17 AAG and carbon ion irradiation in vitro and in vivo xenograft model when compared with carbon irradiation alone. The cause of this radio-enhancement effect seems to come from the inhibition of repair of DNA DSBs by 17AAG as shown in the case of X-rays. We have also confirmed that the homologous recombination repair pathway was affected by the addition of 17AAG in carbon irradiated tumor cells. We have recently started to investigate another Hsp90 inhibitor PU-H71 with carbon ion irradiation in vitro and in vivo. Our data indicate that PU-H71 pre-treatment also gave a significant radio-sensitization in SQ5 human lung tumor cells exposed to carbon ions. In vivo xenograft study is currently ongoing and further data including some mechanistic insight for the PU-H71 radio-sensitization will be presented. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | HITSRS2013 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-05-18 | |||||
| 日付タイプ | Issued | |||||
