@misc{oai:repo.qst.go.jp:00065014,
 author = {Okayasu, Ryuichi and Hirakawa, Hirokazu and Masaoka, Aya and Noguchi, Miho and Hirayama, Ryoichi and Li, Huizi and Matsumoto, Yoshitaka and Fujimori, Akira and 岡安 隆一 and 平川 博一 and 正岡 綾 and 平山 亮一 and 李 惠子 and 松本 孔貴 and 藤森 亮},
 month = {May},
 note = {We have shown an Hsp90 inhibitor 17AAG can be an effective radio-sensitizer with X-rays for certain human tumor cells, while normal cells were not sensitized by this drug. The underlying mechanism for this effect was shown to be inhibition of DNA double strand breaks (DSBs) by 17AAG. In vivo mouse xenograft study also showed a better tumor control with the pretreatment of this drug when compared with X-ray treatment alone. We have extended the combination study to carbon ion irradiation in vitro and in vivo. Our data indicate that cancer cells are also controlled better with the combination of 17 AAG and carbon ion irradiation in vitro and in vivo xenograft model when compared with carbon irradiation alone. The cause of this radio-enhancement effect seems to come from the inhibition of repair of DNA DSBs by 17AAG as shown in the case of X-rays. We have also confirmed that the homologous recombination repair pathway was affected by the addition of 17AAG in carbon irradiated tumor cells. 
   We have recently started to investigate another Hsp90 inhibitor PU-H71 with carbon ion irradiation in vitro and in vivo. Our data indicate that PU-H71 pre-treatment also gave a significant radio-sensitization in SQ5 human lung tumor cells exposed to carbon ions. In vivo xenograft study is currently ongoing and further data including some mechanistic insight for the PU-H71 radio-sensitization will be presented., HITSRS2013},
 title = {Hsp90 inhibitor is a good candidate for effective combination therapy with carbon ions},
 year = {2013}
}