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Mammary carcinogenesis after exposure of fetal, neonatal, juvenile and adult rats to gamma rays and carbon ions.
https://repo.qst.go.jp/records/65012
https://repo.qst.go.jp/records/65012f1ebdb42-57f2-42dd-b2d4-ebdd168c99ab
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-05-23 | |||||
| タイトル | ||||||
| タイトル | Mammary carcinogenesis after exposure of fetal, neonatal, juvenile and adult rats to gamma rays and carbon ions. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Nishimura, Mayumi× Daino, Kazuhiro× Kokubo, Toshiaki× Doi, Kazutaka× Iizuka, Daisuke× Nishimura, Yukiko× Takabatake, Masaru× Kakinuma, Shizuko× Shimada, Yoshiya× 今岡 達彦× 西村 まゆみ× 臺野 和広× 小久保 年章× 土居 主尚× 飯塚 大輔× 西村 由希子× 高畠 賢× 柿沼 志津子× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The risk of developing secondary cancer after radiotherapy, especially after treatment of childhood cancers, remains a matter of concern. The high biological effects of carbon-ion radiation have enabled powerful radiotherapy, yet the approach is commonly restricted to the treatment of adults. The present study is aimed to investigate the effect of carbon-ion irradiation in childhood on breast carcinogenesis. We irradiated female Sprague-Dawley rats of various ages (embryonic days 3, 13 and 17, and 1, 3, 7 and 15 weeks after birth) with 137Cs gamma rays or a 290-MeV/u monoenergetic carbon-ion beam (linear energy transfer, 13 keV/um). All animals were screened weekly for mammary carcinoma by palpation until they were 90 weeks old. Irradiation of fetal and mature (15-week-old) rats with either radiation source at a dose of 0.2 or 1 Gy did not substantially increase the hazard ratio compared to the non-irradiated group. Dose responses (0.2-2.0 Gy) to gamma rays were similar among the groups of rats irradiated 1, 3 and 7 weeks after birth. The effect of carbon ions increased along with the age at the time of irradiation, indicating relative biological effectiveness values of 0.2 [-0.3, 0.7], 1.3 [1.0, 1.6] and 2.8 [1.8, 3.9] (mean and 95% confidence interval) for animals that were 1, 3 and 7 weeks of age, respectively. Our findings imply that carbon-ion therapy may be associated with a risk of secondary breast cancer in humans, the extent of which may depend on the age of the patient at the time of irradiation. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Heavy Ion in Therapy and Space Radiation Symposium 2013 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-05-18 | |||||
| 日付タイプ | Issued | |||||
