{"created":"2023-05-15T14:47:24.775715+00:00","id":65012,"links":{},"metadata":{"_buckets":{"deposit":"9751781f-cb2d-4a98-8935-4020ca1af7ac"},"_deposit":{"created_by":1,"id":"65012","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65012"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065012","sets":["10:29"]},"author_link":["640602","640604","640609","640603","640600","640611","640601","640608","640606","640598","640610","640613","640612","640607","640605","640614","640597","640596","640599","640595"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-18","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The risk of developing secondary cancer after radiotherapy, especially after treatment of childhood cancers, remains a matter of concern. The high biological effects of carbon-ion radiation have enabled powerful radiotherapy, yet the approach is commonly restricted to the treatment of adults. The present study is aimed to investigate the effect of carbon-ion irradiation in childhood on breast carcinogenesis. \nWe irradiated female Sprague-Dawley rats of various ages (embryonic days 3, 13 and 17, and 1, 3, 7 and 15 weeks after birth) with 137Cs gamma rays or a 290-MeV/u monoenergetic carbon-ion beam (linear energy transfer, 13 keV/um). All animals were screened weekly for mammary carcinoma by palpation until they were 90 weeks old. \nIrradiation of fetal and mature (15-week-old) rats with either radiation source at a dose of 0.2 or 1 Gy did not substantially increase the hazard ratio compared to the non-irradiated group. Dose responses (0.2-2.0 Gy) to gamma rays were similar among the groups of rats irradiated 1, 3 and 7 weeks after birth. The effect of carbon ions increased along with the age at the time of irradiation, indicating relative biological effectiveness values of 0.2 [-0.3, 0.7], 1.3 [1.0, 1.6] and 2.8 [1.8, 3.9] (mean and 95% confidence interval) for animals that were 1, 3 and 7 weeks of age, respectively. \nOur findings imply that carbon-ion therapy may be associated with a risk of secondary breast cancer in humans, the extent of which may depend on the age of the patient at the time of irradiation.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Heavy Ion in Therapy and Space Radiation Symposium 2013","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imaoka, Tatsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"640595","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"640596","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Daino, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"640597","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kokubo, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"640598","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Doi, Kazutaka"}],"nameIdentifiers":[{"nameIdentifier":"640599","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iizuka, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"640600","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"640601","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takabatake, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"640602","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"640603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"640604","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"臺野 和広","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小久保 年章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"土居 主尚","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"飯塚 大輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 由希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畠 賢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640614","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Mammary carcinogenesis after exposure of fetal, neonatal, juvenile and adult rats to gamma rays and carbon ions.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mammary carcinogenesis after exposure of fetal, neonatal, juvenile and adult rats to gamma rays and carbon ions."}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-05-23"},"publish_date":"2013-05-23","publish_status":"0","recid":"65012","relation_version_is_last":true,"title":["Mammary carcinogenesis after exposure of fetal, neonatal, juvenile and adult rats to gamma rays and carbon ions."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:05:03.701685+00:00"}