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アイテム
Total-body low dose irradiation of mice induces neither learning disability and memory impairment in Morris water maze test nor Alzheimer s disease-like pathogensis in the brain.
https://repo.qst.go.jp/records/65004
https://repo.qst.go.jp/records/650048c32e5ef-b023-4809-bef6-0abea105cbcc
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-05-22 | |||||
| タイトル | ||||||
| タイトル | Total-body low dose irradiation of mice induces neither learning disability and memory impairment in Morris water maze test nor Alzheimer s disease-like pathogensis in the brain. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Tanaka, Kaoru× Ki, Hin× Ono, Maiko× Hou, Yagun× Ninomiya, Yasuharu× Maruyama, Kouichi× Nakajima, Nakako× Begum, Nasrin× Higuchi, Makoto× Fujimori, Akira× Uehara, Yoshihiko× Nakajima, Tetsuo× Suhara, Tetsuya× Ono, Tetsuya× Nenoi, Mitsuru× 王 冰× 田中 薫× 季 斌× 小野 麻衣子× 方 雅群× 二宮 康晴× 丸山 耕一× 中島 菜花子× ＢＥＧＵＭ ＮＡＳＲＩＮ× 樋口 真人× 藤森 亮× 中島 徹夫× 須原 哲也× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Alzheimer s disease (AD) is the most common form of dementia while its cause and progression are not well understood. The possible cognitive and behavioral consequences induced by low-dose radiation are of great concern as humans are exposed to ionizing radiations from various sources including medical diagnosis. A recent study in mice reported early transcriptional response in brain to low-dose X-rays (0.10 Gy) suggesting alterations of molecular networks and pathways associated with cognitive functions, advanced aging and AD. To investigate the late pathological, cognitive and behavioral consequences induced by low-dose radiation, C57BL/6J mice were total-body irradiated with an acute dose from X-rays (0.10 Gy) or carbon ions (0.05 or 0.10 Gy). The hippocampus was collected and the expression of 84 AD-related genes was analyzed. Morris water maze test was applied to the measurement of the learning ability and memory of the animals. Amyloid imaging with positron emission tomography (PET) were performed to detect the accumulation of fibrillary amyloid eta peptide (Ab, and characteristic pathologies of AD were examined with immunohistochemical staining of amyloid precursor protein (APP), A, tau and phosphorylated tau. For the transcriptional studies, results showed that a few genes out of 84 AD-related genes were significantly up-regulated at 4 hours after irradiation and the other genes had no marked change; on the other hand, a few other genes showed a significant down-regulation while the other genes had no marked change at 1 year after irradiation. For the behavioral studies, no significant difference on learning ability and memory was observed at 1 year and 2 years after irradiation. Imaging and immunohistochemical staining showed no change in the accumulation of fibrillar amyloid and the expression of APP, A, tau, phosphorylated tau were detectable in the animals 4 months and 2 years after irradiation. These findings suggest that total-body irradiation at a dose of 0.10 Gy could hardly induce early or late transcriptional alteration in most of the AD-related genes, learning disability and memory impairment, and AD-like pathological change in the brain in mice. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Heavy ion in therapy and space radiation symposium 2013. | |||||
| 発表年月日 | ||||||
| 日付 | 2013-05-18 | |||||
| 日付タイプ | Issued | |||||
