@misc{oai:repo.qst.go.jp:00065004,
 author = {Bing, Wang and Tanaka, Kaoru and Ki, Hin and Ono, Maiko and Hou, Yagun and Ninomiya, Yasuharu and Maruyama, Kouichi and Nakajima, Nakako and Begum, Nasrin and Higuchi, Makoto and Fujimori, Akira and Uehara, Yoshihiko and Nakajima, Tetsuo and Suhara, Tetsuya and Ono, Tetsuya and Nenoi, Mitsuru and 王 冰 and 田中 薫 and 季 斌 and 小野 麻衣子 and 方 雅群 and 二宮 康晴 and 丸山 耕一 and 中島 菜花子 and ＢＥＧＵＭ ＮＡＳＲＩＮ and 樋口 真人 and 藤森 亮 and 中島 徹夫 and 須原 哲也 and 根井 充},
 month = {May},
 note = {Alzheimer s disease (AD) is the most common form of dementia while its cause and progression are not well understood. The possible cognitive and behavioral consequences induced by low-dose radiation are of great concern as humans are exposed to ionizing radiations from various sources including medical diagnosis. A recent study in mice reported early transcriptional response in brain to low-dose X-rays (0.10 Gy) suggesting alterations of molecular networks and pathways associated with cognitive functions, advanced aging and AD. To investigate the late pathological, cognitive and behavioral consequences induced by low-dose radiation, C57BL/6J mice were total-body irradiated with an acute dose from X-rays (0.10 Gy) or carbon ions (0.05 or 0.10 Gy). The hippocampus was collected and the expression of 84 AD-related genes was analyzed. Morris water maze test was applied to the measurement of the learning ability and memory of the animals. Amyloid imaging with positron emission tomography (PET) were performed to detect the accumulation of fibrillary amyloid eta peptide (Ab, and characteristic pathologies of AD were examined with immunohistochemical staining of amyloid precursor protein (APP), A, tau and phosphorylated tau. For the transcriptional studies, results showed that a few genes out of 84 AD-related genes were significantly up-regulated at 4 hours after irradiation and the other genes had no marked change; on the other hand, a few other genes showed a significant down-regulation while the other genes had no marked change at 1 year after irradiation. For the behavioral studies, no significant difference on learning ability and memory was observed at 1 year and 2 years after irradiation. Imaging and immunohistochemical staining showed no change in the accumulation of fibrillar amyloid and the expression of APP, A, tau, phosphorylated tau were detectable in the animals 4 months and 2 years after irradiation. These findings suggest that total-body irradiation at a dose of 0.10 Gy could hardly induce early or late transcriptional alteration in most of the AD-related genes, learning disability and memory impairment, and AD-like pathological change in the brain in mice., Heavy ion in therapy and space radiation symposium 2013.},
 title = {Total-body low dose irradiation of mice induces neither learning disability and memory impairment in Morris water maze test nor Alzheimer s disease-like pathogensis in the brain.},
 year = {2013}
}