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PET quantitative analysis of changes in receptor binding with multiple injections
https://repo.qst.go.jp/records/64984
https://repo.qst.go.jp/records/64984c0e1edb0-77f5-43c6-8791-3e79bc2e2251
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-05-01 | |||||
| タイトル | ||||||
| タイトル | PET quantitative analysis of changes in receptor binding with multiple injections | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ikoma, Youko
× Ikoma, Youko× Ito, Hiroshi× 生駒 洋子× 伊藤 浩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Positron emission tomography (PET) with [11C]raclopride is widely used to investigate temporal changes in the dopamine D2 receptor system attributed to the endogenous dopamine release. However, in assessing temporal changes in the binding potential (BPND) using a conventional simplified reference tissue model (SRTM), multiple [11C]raclopride PET scans are required. In this study, we have developed an multiple-injection SRTM to estimate the BPND change from a single PET scan with multiple injections of [11C]raclopride, and validated this approach by performing numerous simulations. In the simulations, TACs were generated for dual injections of [11C]raclopride in which dopamine release changed during the scans, and the change in BPND were estimated by the proposed method. As a result, the reduction in BPND was correlated with the integral of released dopamine. The proposed multiple-injection approach shortened scan period for the quantitative assessment of the BPND change for neurotransmitter competition studies. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2nd SNU-NIRS Workshop on Nuclear Medicine Imaging Science and Technology | |||||
| 発表年月日 | ||||||
| 日付 | 2013-04-25 | |||||
| 日付タイプ | Issued | |||||
