@misc{oai:repo.qst.go.jp:00064984,
 author = {Ikoma, Youko and Ito, Hiroshi and 生駒 洋子 and 伊藤 浩},
 month = {Apr},
 note = {Positron emission tomography (PET) with [11C]raclopride is widely used to investigate temporal changes in the dopamine D2 receptor system attributed to the endogenous dopamine release. However, in assessing temporal changes in the binding potential (BPND) using a conventional simplified reference tissue model (SRTM), multiple [11C]raclopride PET scans are required. In this study, we have developed an multiple-injection SRTM to estimate the BPND change from a single PET scan with multiple injections of [11C]raclopride, and validated this approach by performing numerous simulations. In the simulations, TACs were generated for dual injections of [11C]raclopride in which dopamine release changed during the scans, and the change in BPND were estimated by the proposed method. As a result, the reduction in BPND was correlated with the integral of released dopamine. The proposed multiple-injection approach shortened scan period for the quantitative assessment of the BPND change for neurotransmitter competition studies., 2nd SNU-NIRS Workshop on Nuclear Medicine Imaging Science and Technology},
 title = {PET quantitative analysis of changes in receptor binding with multiple injections},
 year = {2013}
}