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多変量解析による鼻腔悪性黒色腫の重粒子線治療効果予測因子の検討：11C-Methionine PETとその他基本因子
https://repo.qst.go.jp/records/64873
https://repo.qst.go.jp/records/648734b4a0692-f081-4f03-8c93-fbde872e9e94
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-12-12 | |||||
| タイトル | ||||||
| タイトル | 多変量解析による鼻腔悪性黒色腫の重粒子線治療効果予測因子の検討：11C-Methionine PETとその他基本因子 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
大橋, 靖也
× 大橋, 靖也× 吉川, 京燦× 桃原, 幸子× 長谷部, 充彦× 石川, 博之× 谷本, 克之× 福村, 利光× 長谷川, 安都佐× 佐賀, 恒夫× 神立, 進× 鎌田, 正× 大橋 靖也× 吉川 京燦× 桃原 幸子× 長谷部 充彦× 石川 博之× 谷本 克之× 福村 利光× 長谷川 安都佐× 佐賀 恒夫× 神立 進× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with Malignant Melanoma in nasal cavity. We evaluated whether the L-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis and the prognosis in patients with Malignant Melanoma in nasal cavity. Methods: Forty-six patients were prospectively studied by MET-positron emission tomography (PET) before and about 1 month after CIRT. The tumor MET uptake was measured with the semiquantitative tumor to normal tissue ratio (TNR). The tumor TNR and relevant clinical parameters were then evaluated by both univariate and multivariate analyses. Results: The average TNRs before and after the treatment were 7.0 (+/-4.4) and 5.1 (+/-2.7), respectively, and significant differences were observed between them. In a univariate analysis, local recurrence was observed more frequently in the group with a higher TNR before the treatment than a lower TNR (cut-off value was 6.2), and the prognosis was poor in the group with a higher TNR before and after the treatment than a lower TNR (cut-off values were 4.4 and 7.4, respectively). In a multivariate analysis, significant differences was observed for relationship between the TNR before the treatment and prognosis. No significant difference was observed for relationship between TNR after the treatment and the treatment results. Conclusions: The determination of treatment effectiveness using TNR in CIRT for nasal cavity Malignant Melanoma is an independent factor for predicting prognosis. MET-PET is therefore considered to be useful for determining the treatment effectiveness in patients with nasal cavity Malignant Melanoma undergoing CIRT. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成23年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2012-04-24 | |||||
| 日付タイプ | Issued | |||||
