@misc{oai:repo.qst.go.jp:00064873,
 author = {大橋, 靖也 and 吉川, 京燦 and 桃原, 幸子 and 長谷部, 充彦 and 石川, 博之 and 谷本, 克之 and 福村, 利光 and 長谷川, 安都佐 and 佐賀, 恒夫 and 神立, 進 and 鎌田, 正 and 大橋 靖也 and 吉川 京燦 and 桃原 幸子 and 長谷部 充彦 and 石川 博之 and 谷本 克之 and 福村 利光 and 長谷川 安都佐 and 佐賀 恒夫 and 神立 進 and 鎌田 正},
 month = {Apr},
 note = {Purpose: Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with Malignant Melanoma in nasal cavity. We evaluated whether the L-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis and the prognosis in patients with Malignant Melanoma in nasal cavity. 
Methods: Forty-six patients were prospectively studied by MET-positron emission tomography (PET) before and about 1 month after CIRT. The tumor MET uptake was measured with the semiquantitative tumor to normal tissue ratio (TNR). The tumor TNR and relevant clinical parameters were then evaluated by both univariate and multivariate analyses.
Results: The average TNRs before and after the treatment were 7.0 (+/-4.4) and 5.1 (+/-2.7), respectively, and significant differences were observed between them.
 In a univariate analysis, local recurrence was observed more frequently in the group with a higher TNR before the treatment than a lower TNR (cut-off value was 6.2), and the prognosis was poor in the group with a higher TNR before and after the treatment than a lower TNR (cut-off values were 4.4 and 7.4, respectively). 
In a multivariate analysis, significant differences was observed for relationship between the TNR before the treatment and prognosis.  No significant difference was observed for relationship between TNR after the treatment and the treatment results. 
Conclusions: The determination of treatment effectiveness using TNR in CIRT for nasal cavity Malignant Melanoma is an independent factor for predicting prognosis. MET-PET is therefore considered to be useful for determining the treatment effectiveness in patients with nasal cavity Malignant Melanoma undergoing CIRT., 平成23年度HIMAC共同利用研究成果発表会},
 title = {多変量解析による鼻腔悪性黒色腫の重粒子線治療効果予測因子の検討：11C-Methionine PETとその他基本因子},
 year = {2012}
}