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低線量率長期照射によるマウス肝臓での遺伝子発現変化の経時的・長期的解析
https://repo.qst.go.jp/records/64727
https://repo.qst.go.jp/records/6472799520f65-c29b-4306-93cc-6dc8f678dede
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-09-14 | |||||
| タイトル | ||||||
| タイトル | 低線量率長期照射によるマウス肝臓での遺伝子発現変化の経時的・長期的解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
上原, 芳彦
× 上原, 芳彦× 王, 冰× 中島, 徹夫× 根井, 充× 小野, 哲也× 上原 芳彦× 王 冰× 中島 徹夫× 根井 充× 小野 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To assess the biological effects of long-term low-dose-rate gamma irradiation, the induced transcriptional changes were analyzed by DNA microarray using Affymetrix Mouse Genome 430 2.0 GeneChips. C57BL/6J mice were exposed at a dose-rate of 20 mGy/day. 1 mGy/day and 0.05 mGy/day for 400 days. The exposure levels of the dose-rates of 1 mGy/day and 0.05 mGy/day correspond to those of astronauts in space and the dose limit for radiation workers, respectively. Results showed that the expression levels of 20 genes, 11 genes and 3 genes were modulated to more than 1.5-fold in all 6 mice immediately after the irradiation at 20mGy/day, 1mGy/day and 0.05mGy/day, respectively (Radiat.Res. (2010) 174, 611-617). Next, the modulation kinetics of gene expression was investigated. The modulation of expression after irradiation at 20mGy/day was not maintained for 24 hours after the irradiation. As some effects of low-dose-rate irradiation have been reported to emerge late after the end of irradiation, the microarray analysis of the liver 3 months after the irradiation was conducted. Although there is very little overlap between the genes modulated immediately and 3 months after the irradiation, the functional analysis using Ingenuity Pathways Analysis (IPA) suggested that both gene groups were commonly related to those involved in lipid metabolism. IPA study also suggested a most significant relationship between the modulated genes and those involved in liver tumorigenesis. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第５５回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2012-09-08 | |||||
| 日付タイプ | Issued | |||||
