{"created":"2023-05-15T14:47:12.021201+00:00","id":64727,"links":{},"metadata":{"_buckets":{"deposit":"a97c9982-cc6c-40a9-af41-5bf6f1a9e5eb"},"_deposit":{"created_by":1,"id":"64727","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64727"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064727","sets":["10:29"]},"author_link":["637786","637785","637788","637782","637787","637791","637789","637790","637783","637784"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-09-08","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To assess the biological effects of long-term low-dose-rate gamma irradiation, the induced transcriptional changes were analyzed by DNA microarray using Affymetrix Mouse Genome 430 2.0 GeneChips. C57BL/6J mice were exposed at a dose-rate of 20 mGy/day. 1 mGy/day and 0.05 mGy/day for 400 days. The exposure levels of the dose-rates of 1 mGy/day and 0.05 mGy/day correspond to those of astronauts in space and the dose limit for radiation workers, respectively. Results showed that the expression levels of 20 genes, 11 genes and 3 genes were modulated to more than 1.5-fold in all 6 mice immediately after the irradiation at 20mGy/day, 1mGy/day and 0.05mGy/day, respectively (Radiat.Res. (2010) 174, 611-617). Next, the modulation kinetics of gene expression was investigated. The modulation of expression after irradiation at 20mGy/day was not maintained for 24 hours after the irradiation. As some effects of low-dose-rate irradiation have been reported to emerge late after the end of irradiation, the microarray analysis of the liver 3 months after the irradiation was conducted. Although there is very little overlap between the genes modulated immediately and 3 months after the irradiation, the functional analysis using Ingenuity Pathways Analysis (IPA) suggested that both gene groups were commonly related to those involved in lipid metabolism. IPA study also suggested a most significant relationship between the modulated genes and those involved in liver tumorigenesis.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第５５回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上原, 芳彦"}],"nameIdentifiers":[{"nameIdentifier":"637782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"637783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島, 徹夫"}],"nameIdentifiers":[{"nameIdentifier":"637784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井, 充"}],"nameIdentifiers":[{"nameIdentifier":"637785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"637786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上原 芳彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 徹夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637791","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"低線量率長期照射によるマウス肝臓での遺伝子発現変化の経時的・長期的解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"低線量率長期照射によるマウス肝臓での遺伝子発現変化の経時的・長期的解析"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-09-14"},"publish_date":"2012-09-14","publish_status":"0","recid":"64727","relation_version_is_last":true,"title":["低線量率長期照射によるマウス肝臓での遺伝子発現変化の経時的・長期的解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:08:19.876366+00:00"}