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膵臓癌幹細胞様細胞における炭素線の影響
https://repo.qst.go.jp/records/64345
https://repo.qst.go.jp/records/6434510c3aecf-e170-4443-af95-16e94db53a4d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-07 | |||||
| タイトル | ||||||
| タイトル | 膵臓癌幹細胞様細胞における炭素線の影響 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
大西, 和彦
× 大西, 和彦× 崔, 星× 山田, 滋× 横須賀, 収× 鎌田, 正× 大西 和彦× 崔 星× 山田 滋× 横須賀 収× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Heavy ion medical accelerator in Chiba(HIMAC) has been successful in treating various radioresistant human cancers and achieved high radiocurability. We investigated whether a carbon ion beam has beneficial effects compared to X-rays by targeting putative human pancreatic cancer stem cells. Materials: Human pancreatic cancer stem-like cells sorted from MiaPaCa2 and BxPc3 cells were treated with or without carbon ion or X-ray irradiation and then colony formation assay, spheroid formation assay, and FACS analysis were performed. Results: CD44+/CD24+cells sorted from BxPc-3 and MiaPaCa-2 exactly had a higher ability for colony, spheroid formation, and tumor formation ability in NOD/SCID mice compaered to CD44-/CD24- cells. The proportion of CD44+/CD24+ cells was more significantly enriched by X-ray irradiation compared to carbon-ion irradiation at doses of same biological efficacy. CD44-/CD24- cells were radiosensitivity for both X-ray and carbon-ion beam, whereas CD44+/CD24+ cells were radioresistance to both X-ray and carbon-ion beam, but the RBE values of carbon ion relative to X-rays irradiation at D10 level were ranged from 2.0 to 2.35, suggesting that carbon-ion beam had more efficacy to kill CD44+/CD24+ cells. Conclusions: Carbon ion irradiation has potential advantages over X-rays in targeting radioresistant pancreatic cancer stem-like cells. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第70回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2011-10-05 | |||||
| 日付タイプ | Issued | |||||
