{"created":"2023-05-15T14:46:54.124272+00:00","id":64345,"links":{},"metadata":{"_buckets":{"deposit":"79cfce3d-3dbf-429d-b058-b6d4d2884666"},"_deposit":{"created_by":1,"id":"64345","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64345"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064345","sets":["10:29"]},"author_link":["634410","634416","634417","634415","634413","634418","634414","634411","634412","634419"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-10-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Heavy ion medical accelerator in Chiba(HIMAC) has been successful in treating various radioresistant human cancers and achieved high radiocurability. \nWe investigated whether a carbon ion beam has beneficial effects compared to X-rays by targeting putative human pancreatic cancer stem cells.\nMaterials: Human pancreatic cancer stem-like cells sorted from MiaPaCa2 and BxPc3 cells were treated with or without carbon ion or X-ray irradiation and then colony formation assay, spheroid formation assay, and FACS analysis were performed.\nResults: CD44+/CD24+cells sorted from BxPc-3 and MiaPaCa-2 exactly had a higher ability for colony, spheroid formation, and tumor formation ability in NOD/SCID mice compaered to CD44-/CD24- cells. The proportion of CD44+/CD24+ cells was more significantly enriched by X-ray irradiation compared to carbon-ion irradiation at doses of same biological efficacy. CD44-/CD24- cells were radiosensitivity for both X-ray and carbon-ion beam, whereas CD44+/CD24+ cells were radioresistance to both X-ray and carbon-ion beam, but the RBE values of carbon ion relative to X-rays irradiation at D10 level were ranged from 2.0 to 2.35, suggesting that carbon-ion beam had more efficacy to kill CD44+/CD24+ cells.\nConclusions: Carbon ion irradiation has potential advantages over X-rays in targeting radioresistant pancreatic cancer stem-like cells.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第70回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大西, 和彦"}],"nameIdentifiers":[{"nameIdentifier":"634410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔, 星"}],"nameIdentifiers":[{"nameIdentifier":"634411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 滋"}],"nameIdentifiers":[{"nameIdentifier":"634412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横須賀, 収"}],"nameIdentifiers":[{"nameIdentifier":"634413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 正"}],"nameIdentifiers":[{"nameIdentifier":"634414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西 和彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔 星","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横須賀 収","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634419","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"膵臓癌幹細胞様細胞における炭素線の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膵臓癌幹細胞様細胞における炭素線の影響"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-10-07"},"publish_date":"2011-10-07","publish_status":"0","recid":"64345","relation_version_is_last":true,"title":["膵臓癌幹細胞様細胞における炭素線の影響"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:12:40.046662+00:00"}