WEKO3
アイテム
Cancer stem-like cells from a glioblastoma cell line is resistant to X-rays and carbon-ion beams
https://repo.qst.go.jp/records/64344
https://repo.qst.go.jp/records/64344ab99955b-0475-4e1f-a6f6-e136b1c5f69d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-07 | |||||
| タイトル | ||||||
| タイトル | Cancer stem-like cells from a glioblastoma cell line is resistant to X-rays and carbon-ion beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujimori, Akira
× Fujimori, Akira× Hirakawa, Hirokazu× Yajima, Hirohiko× Nakajima, Nakako× 藤森 亮× 平川 博一× 矢島 浩彦× 中島 菜花子 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiotherapy is one of the established treatments for solid tumors. Investigation of tumor radioresistance is important for future tumor radiotherapy. Biological bases on the resistance have not been fully understood. Recent studies have demonstrated that there is a small fraction in solid tumor which is highly resistant to ionizing radiation and the radioresistant tumor cells often expressed some stem cell markers. Resistance of tumors to both radiation and chemotherapeutic agents can be attributed to the features of the cancer stem cells. In the present study, we show that a human glioblastoma cell line A172 transiently becomes to cancer stem cell-like when cultured with non-serum media which is supplemented with growth factors. The treated cell was found significantly resistant to X-rays and heavy ion particles (carbon) compared with the A172 cells cultured with the normal media. Phosphorylation of histon H2Ax was induced in both forms, however, recovered earlier in the stem cell-like population than in the parental cells. Our result is consistent with the hypothesis that cancer stemness causes radioresistance through the efficient activity of DNA double-strand break repair. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第70回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2011-10-05 | |||||
| 日付タイプ | Issued | |||||
