@misc{oai:repo.qst.go.jp:00064344,
 author = {Fujimori, Akira and Hirakawa, Hirokazu and Yajima, Hirohiko and Nakajima, Nakako and 藤森 亮 and 平川 博一 and 矢島 浩彦 and 中島 菜花子},
 month = {Oct},
 note = {Radiotherapy is one of the established treatments for solid tumors. Investigation of tumor radioresistance is important for future tumor radiotherapy. Biological bases on the resistance have not been fully understood. Recent studies have demonstrated that there is a small fraction in solid tumor which is highly resistant to ionizing radiation and the radioresistant tumor cells often expressed some stem cell markers. Resistance of tumors to both radiation and chemotherapeutic agents can be attributed to the features of the cancer stem cells. In the present study, we show that a human glioblastoma cell line A172 transiently becomes to cancer stem cell-like when cultured with non-serum media which is supplemented with growth factors. The treated cell was found significantly resistant to X-rays and heavy ion particles (carbon) compared with the A172 cells cultured with the normal media. Phosphorylation of histon H2Ax was induced in both forms, however, recovered earlier in the stem cell-like population than in the parental cells. Our result is consistent with the hypothesis that cancer stemness causes radioresistance through the efficient activity of DNA double-strand break repair., 第70回日本癌学会学術総会},
 title = {Cancer stem-like cells from a glioblastoma cell line is resistant to X-rays and carbon-ion beams},
 year = {2011}
}