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放射線により誘発される突然変異の新展開
https://repo.qst.go.jp/records/64241
https://repo.qst.go.jp/records/6424134c52a4d-6e80-4b17-9eec-310e861a9047
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-04-04 | |||||
| タイトル | ||||||
| タイトル | 放射線により誘発される突然変異の新展開 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
山内, 正剛
× 山内, 正剛× 坂上, 万里× 山内 正剛× 坂上 万里 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We isolated and examined mouse mutant cells exhibiting phenotype plasticity. Approximately 10% of 6-thioguanine resistant (6TGR) cells derived from the irradiated cell population exhibited phenotype plasticity and reverted to wild type HAT resistance (HATR). Treatment with 5-aza-cytidine (5AC) did not affect phenotype plasticity. Detailed molecular analysis of the promoter region of the hypoxanthine phosphoribosyl transferase (Hprt) gene confirmed the result of 5AC experiment, revealing that most cytidine residues were not methylated, even in 6TGR mutant cells, in which Hprt activity must be down-regulated. These results suggested that DNA methylation was not involved in mutant phenotype plasticity, a new type of genomic instability induced by ionizing radiation. Phenotype plasticity may play an important role in radiation carcinogenesis, which is a multiple-stage process. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第4回21世紀科学と人間シンポジウム | |||||
| 発表年月日 | ||||||
| 日付 | 2011-03-30 | |||||
| 日付タイプ | Issued | |||||
