@misc{oai:repo.qst.go.jp:00064241,
 author = {山内, 正剛 and 坂上, 万里 and 山内 正剛 and 坂上 万里},
 month = {Mar},
 note = {We isolated and examined mouse mutant cells exhibiting phenotype plasticity.  Approximately 10% of 6-thioguanine resistant (6TGR) cells derived from the irradiated cell population exhibited phenotype plasticity and reverted to wild type HAT resistance (HATR).  Treatment with 5-aza-cytidine (5AC) did not affect phenotype plasticity.  Detailed molecular analysis of the promoter region of the hypoxanthine phosphoribosyl transferase (Hprt) gene confirmed the result of 5AC experiment, revealing that most cytidine residues were not methylated, even in 6TGR mutant cells, in which Hprt activity must be down-regulated.  These results suggested that DNA methylation was not involved in mutant phenotype plasticity, a new type of genomic instability induced by ionizing radiation.  Phenotype plasticity may play an important role in radiation carcinogenesis, which is a multiple-stage process., 第4回21世紀科学と人間シンポジウム},
 title = {放射線により誘発される突然変異の新展開},
 year = {2011}
}