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非小細胞肺癌の炭素イオン線治療前後におけるプロテオーム変化の解析
https://repo.qst.go.jp/records/64232
https://repo.qst.go.jp/records/642328a825bc8-e3ec-4e09-bfba-68221fca9798
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-03-02 | |||||
| タイトル | ||||||
| タイトル | 非小細胞肺癌の炭素イオン線治療前後におけるプロテオーム変化の解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
中嶋, 美緒
× 中嶋, 美緒× 梅村, 啓史× 馬場, 雅行× 山本, 直敬× 本村, 真理× 山田, 泰寿× 清水, 一範× 須金, 紀雄× 朝長, 毅× 野村, 文夫× 溝江, 純悦× 鎌田, 正× 中嶋 美緒× 馬場 雅行× 山本 直敬× 本村 真理× 山田 泰寿× 清水 一範× 須金 紀雄× 溝江 純悦× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose:Carbon ion radiotherapy(CIRT)for non-small cell lung cancer(NSCLC)is an effective and low invasive therapy. But local recurrence occurred in nearly 10% of all the treated lesions, and about 3% of the patients after CIRT develop radiation pneumonitis to need treatment. In this study,we aimed to explore that reflect the effect of CIRT on NSCLC and useful for early diagnosis of local recurrence or severe radiation pneumonitis. Methods and Materials:We enrolled 36 NSCLC patients who underwent CIRT. Serum samples were collected from these patients before treatment and 1 day and 1, 3, 6 months after treatment. We then prepared 5 µL of serum with magnetic beads and profiled serum proteom using MALDI-TOF MS. Results:We obtained 83 peaks with WCXbeads,79 peaks with IMAC-Cu beads and 83 peaks with C8 beads. Nine peaks showed significant differences(p<0.05) after the therapy. We identified the 2861 Da peak as a fibrinogen alph chain fragment. The 2861 Da peptide was upregulated soon after irradiation and then declined immediately, and this change was dependent on the dose per fraction. Conclusions:These serum peptides were considered to reflect the vital reaction and treatment effect after CIRT. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H21年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-04-20 | |||||
| 日付タイプ | Issued | |||||
