@misc{oai:repo.qst.go.jp:00064232,
 author = {中嶋, 美緒 and 梅村, 啓史 and 馬場, 雅行 and 山本, 直敬 and 本村, 真理 and 山田, 泰寿 and 清水, 一範 and 須金, 紀雄 and 朝長, 毅 and 野村, 文夫 and 溝江, 純悦 and 鎌田, 正 and 中嶋 美緒 and 馬場 雅行 and 山本 直敬 and 本村 真理 and 山田 泰寿 and 清水 一範 and 須金 紀雄 and 溝江 純悦 and 鎌田 正},
 month = {Apr},
 note = {Purpose:Carbon ion radiotherapy(CIRT)for non-small cell lung cancer(NSCLC)is an effective and low invasive therapy. But local recurrence occurred in nearly 10% of all the treated lesions, and about 3% of the patients after CIRT develop radiation pneumonitis to need treatment. In this study,we aimed to explore that reflect the effect of CIRT on NSCLC and useful for early diagnosis of local recurrence or severe radiation pneumonitis.
Methods and Materials:We enrolled 36 NSCLC patients who underwent CIRT. Serum samples were collected from these patients before treatment and 1 day and 1, 3, 6 months after treatment. We then prepared 5 µL of serum with magnetic beads and profiled serum proteom using MALDI-TOF MS.
Results:We obtained 83 peaks with WCXbeads,79 peaks with IMAC-Cu beads and 83 peaks with C8 beads. Nine peaks showed significant differences(p<0.05) after the therapy. We identified the 2861 Da peak as a fibrinogen alph chain fragment. The 2861 Da peptide was upregulated soon after irradiation and then declined immediately, and this change was dependent on the dose per fraction.
Conclusions:These serum peptides were considered to reflect the vital reaction and treatment effect after CIRT., H21年度HIMAC共同利用研究成果発表会},
 title = {非小細胞肺癌の炭素イオン線治療前後におけるプロテオーム変化の解析},
 year = {2010}
}