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マンガン増感磁気共鳴イメージングによる中皮腫の検出
https://repo.qst.go.jp/records/64026
https://repo.qst.go.jp/records/6402697835ebf-89b2-4c30-be85-c64167ffa29d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-09-28 | |||||
| タイトル | ||||||
| タイトル | マンガン増感磁気共鳴イメージングによる中皮腫の検出 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
長谷川, 純崇
× 長谷川, 純崇× 越川, 道子× 古川, 高子× 佐賀, 恒夫× 長谷川 純崇× 越川 道子× 古川 高子× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We show that manganese-enhanced magnetic resonance imaging (MEMRI) represents a promising approach for a more selective molecular imaging of malignant mesothelioma (MM) by monitoring a high-level expression of manganese-superoxide dismutase (Mn-SOD), which is observed in many MM. We found that NCI-H226 human MM cells highly expressed Mn-SOD and augmented Mn accumulation when loaded with manganese chloride (MnCl2). The cells showed marked T1-signal enhancement on in vitro MRI after incubation with MnCl2 because of the T1 shortening effect of Mn2+. Consistent with the in vitro result, H226 subcutaneous tumors were preferentially enhanced compared to another human MM cell tumor, MSTO-211H, which had less Mn-SOD expression, in MnCl2-enhanced T1-weighted MR image, correlating with their respective Mn-SOD expression levels. H226 xenografted pleural tumor (approximately 1 mm diameter) was markedly enhanced and readily detected by MEMRI using manganese dipyridoxyl diphosphate, a clinically used contrast agent, as well as MnCl2. Our data indicate that MEMRI can be a potentially powerful method for non-invasive detection of MM. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第69回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-09-24 | |||||
| 日付タイプ | Issued | |||||
