{"created":"2023-05-15T14:46:39.942842+00:00","id":64026,"links":{},"metadata":{"_buckets":{"deposit":"bdbf9444-1985-44a8-875a-74d58b238375"},"_deposit":{"created_by":1,"id":"64026","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64026"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064026","sets":["10:29"]},"author_link":["631636","631634","631641","631639","631637","631640","631638","631635"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-09-24","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We show that manganese-enhanced magnetic resonance imaging (MEMRI) represents a promising approach for a more selective molecular imaging of malignant mesothelioma (MM) by monitoring a high-level expression of manganese-superoxide dismutase (Mn-SOD), which is observed in many MM. We found that NCI-H226 human MM cells highly expressed Mn-SOD and augmented Mn accumulation when loaded with manganese chloride (MnCl2). The cells showed marked T1-signal enhancement on in vitro MRI after incubation with MnCl2 because of the T1 shortening effect of Mn2+. Consistent with the in vitro result, H226 subcutaneous tumors were preferentially enhanced compared to another human MM cell tumor, MSTO-211H, which had less Mn-SOD expression, in MnCl2-enhanced T1-weighted MR image, correlating with their respective Mn-SOD expression levels. H226 xenografted pleural tumor (approximately 1 mm diameter) was markedly enhanced and readily detected by MEMRI using manganese dipyridoxyl diphosphate, a clinically used contrast agent, as well as MnCl2. Our data indicate that MEMRI can be a potentially powerful method for non-invasive detection of MM.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第69回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長谷川, 純崇"}],"nameIdentifiers":[{"nameIdentifier":"631634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"越川, 道子"}],"nameIdentifiers":[{"nameIdentifier":"631635","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 高子"}],"nameIdentifiers":[{"nameIdentifier":"631636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"631637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 純崇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"越川 道子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631641","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"マンガン増感磁気共鳴イメージングによる中皮腫の検出","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マンガン増感磁気共鳴イメージングによる中皮腫の検出"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-09-28"},"publish_date":"2010-09-28","publish_status":"0","recid":"64026","relation_version_is_last":true,"title":["マンガン増感磁気共鳴イメージングによる中皮腫の検出"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:16:16.410687+00:00"}