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マウス胚性幹細胞由来の神経幹細胞に対する放射線照射の生物学的影響
https://repo.qst.go.jp/records/63753
https://repo.qst.go.jp/records/637539203edb9-16a7-45ca-951a-3eb2e53740b8
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-01-23 | |||||
| タイトル | ||||||
| タイトル | マウス胚性幹細胞由来の神経幹細胞に対する放射線照射の生物学的影響 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
磯野, 真由
× 磯野, 真由× 大津, 昌弘× 新屋, 冬美× 大森, 啓之× 吉江, 拓也× 大谷, 浩樹× 福士, 政広× 中山, 孝× 井上, 順雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The neural stem cells have two features, which are self-renewal and puripotent differentiation which means that they differentiate into neuron, astrocyte and oligodendrocyte. The neural stem cells are present in developmental brain during the fetal period, which grow and differentiate for neurogenesis. In present study found that the neural stem cells are present in specific regions of adult brain. Therefore radiation exposure during the fetal period leads to disturbances in development of the brain and can induce microcephaly or anencephalia. In addition, a recent study shows that radiation influence the cognitive function in adult brain. Those suggest that radiation may affect the neural stem cells related with forming the neurotransmission. Here we investigated the effects of the X-irradiation on the neural stem cells, prepared from mouse embryonic stem (ES) cells by the Neural Stem Sphere (NSS) method. The proliferation of the neural stem cells cultured with fibroblast growth factor-2 (FGF-2) was dose-dependently inhibited by X-irradiation. As for gene expression, nestin and musashi-1 was maintained. It is suggested that the quality of neural stem/precursor cells may be kept. This work was partly supported by a grant of LRI by JCIA and Selective Research Fund of Tokyo Metropolitan University. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第52回日本神経化学会大会, 神経組織の成長・再生・移植研究会 第24回学術集会 連携開催 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-06-24 | |||||
| 日付タイプ | Issued | |||||
