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Evaluation of Reference Tissue Models for the Quantitative Analysis of [11C]PE2I Binding in Human Brain
https://repo.qst.go.jp/records/63621
https://repo.qst.go.jp/records/636211332d08c-a7c0-4b18-a790-e2c38bc0f4a5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-06 | |||||
| タイトル | ||||||
| タイトル | Evaluation of Reference Tissue Models for the Quantitative Analysis of [11C]PE2I Binding in Human Brain | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Seki, Chie
× Seki, Chie× Ito, Hiroshi× Ichimiya, Tetsuya× Arakawa, Ryosuke× Ikoma, Youko× Maeda, Jun× Takano, Akihiro× Takahashi, Hidehiko× Suzuki, Kazutoshi× Suhara, Tetsuya× 関 千江× 伊藤 浩× 一宮 哲哉× 荒川 亮介× 生駒 洋子× 前田 純× 高野 晶寛× 高橋 英彦× 鈴木 和年× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: Dopamine transporter (DAT) plays an important role in presynaptic dopaminergic functions. [11C]PE2I is a highly selective PET ligand for neuronal DAT, and excellent in vivo PET imaging was reported in monkey and human brain [1]. The aim of this study was to find suitable reference tissue model (RTM) for describing tracer kinetics. We analyzed the [11C]PE2I kinetics with metabolite-corrected arterial input function, then we attempted to estimate distribution volume ratio (DVR) with RTMs using cerebellum (CB) as the reference region. The results were compared and assessed the applicability of RTMs with the assistance of a simulation study. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neuroreceptor Mapping 2006 | |||||
| 発表年月日 | ||||||
| 日付 | 2006-07-08 | |||||
| 日付タイプ | Issued | |||||
