@misc{oai:repo.qst.go.jp:00063621, author = {Seki, Chie and Ito, Hiroshi and Ichimiya, Tetsuya and Arakawa, Ryosuke and Ikoma, Youko and Maeda, Jun and Takano, Akihiro and Takahashi, Hidehiko and Suzuki, Kazutoshi and Suhara, Tetsuya and 関 千江 and 伊藤 浩 and 一宮 哲哉 and 荒川 亮介 and 生駒 洋子 and 前田 純 and 高野 晶寛 and 高橋 英彦 and 鈴木 和年 and 須原 哲也}, month = {Jul}, note = {Introduction: Dopamine transporter (DAT) plays an important role in presynaptic dopaminergic functions. [11C]PE2I is a highly selective PET ligand for neuronal DAT, and excellent in vivo PET imaging was reported in monkey and human brain [1]. The aim of this study was to find suitable reference tissue model (RTM) for describing tracer kinetics. We analyzed the [11C]PE2I kinetics with metabolite-corrected arterial input function, then we attempted to estimate distribution volume ratio (DVR) with RTMs using cerebellum (CB) as the reference region. The results were compared and assessed the applicability of RTMs with the assistance of a simulation study., Neuroreceptor Mapping 2006}, title = {Evaluation of Reference Tissue Models for the Quantitative Analysis of [11C]PE2I Binding in Human Brain}, year = {2006} }