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子宮頸癌における重粒子線治療前後のMethionine-PETと62CuATSM-PET診断の比較研究
https://repo.qst.go.jp/records/63253
https://repo.qst.go.jp/records/63253c1e1005c-41a5-4cbd-ac87-b7987a225451
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-09-30 | |||||
| タイトル | ||||||
| タイトル | 子宮頸癌における重粒子線治療前後のMethionine-PETと62CuATSM-PET診断の比較研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
長谷部, 充彦
× 長谷部, 充彦× 吉川, 京燦× 大橋, 靖也× 石川, 博之× 佐合, 賢治× 田巻, 倫明× 加藤, 真吾× 古川, 高子× 福村, 利光× 神立, 進× 鈴木, 和年× 佐賀, 恒夫× 辻井, 博彦× 長谷部 充彦× 吉川 京燦× 大橋 靖也× 石川 博之× 田巻 倫明× 加藤 眞吾× 古川 高子× 福村 利光× 神立 進× 鈴木 和年× 佐賀 恒夫× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Poupose: To determine if Cu-62 labeled diacetyl-bis (N (4)-methylthiosemicarbazone); (Cu-62-ATSM) imaging of tumor hypoxia is associated with C-11-methionine(MET) imaging of amino acid metabolism in cervical cancer. \nMethod: PET/CT was performed in ten patients with cervical cancer for evaluation of both tumor hypoxia using Cu-62-ATSM and amino acid metabolism using MET. Histologically confirmed eight squamous cell carcinoma, four adenocarcima, two adenosquamous carcinoma and melanoma were enrolled in this study. Distribution of Cu-62-ATSM in tumor was compared with that of MET. The two-group system was evaluated the distribution of uptake as Matched (mostly matched with each other) and Mismatched (with each other). Tumor uptake of each tracer was also analyzed semi-quantitatively by Tumor-to-Normal-Tissue-Ratio (TNR). \nResult: Matched and Mismatched-groups were 1 case (6.7%) and 14 cases (93.3%), respectively. In Mismatched-group, Cu-62-ATSM tend to accumulate around the distal margin of high MET uptake area in the tumor. Mean TNR was 9.5 in MET and 4.0 in Cu-62-ATSM, and thus image contrast between tumor and surrounding normal tissue was higher in MET PET/CT image than Cu-62-ATSM PET/CT image. \nConclusion: Cu-62-ATSM and MET showed different distribution in most cases of cervical cancer. Cervical cancer had a greater tendency for the uptake of MET than Cu-62-ATSM. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H20年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-04-14 | |||||
| 日付タイプ | Issued | |||||
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長谷部, 充彦, 吉川, 京燦, 大橋, 靖也, 石川, 博之, 佐合, 賢治, 田巻, 倫明, 加藤, 真吾, 古川, 高子, 福村, 利光, 神立, 進, 鈴木, 和年, 佐賀, 恒夫, 辻井, 博彦, 長谷部 充彦, 吉川 京燦, 大橋 靖也, 石川 博之, 田巻 倫明, 加藤 眞吾, 古川 高子, 福村 利光, 神立 進, 鈴木 和年, 佐賀 恒夫, 辻井 博彦, 2009, 子宮頸癌における重粒子線治療前後のMethionine-PETと62CuATSM-PET診断の比較研究.
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