@misc{oai:repo.qst.go.jp:00063253,
 author = {長谷部, 充彦 and 吉川, 京燦 and 大橋, 靖也 and 石川, 博之 and 佐合, 賢治 and 田巻, 倫明 and 加藤, 真吾 and 古川, 高子 and 福村, 利光 and 神立, 進 and 鈴木, 和年 and 佐賀, 恒夫 and 辻井, 博彦 and 長谷部 充彦 and 吉川 京燦 and 大橋 靖也 and 石川 博之 and 田巻 倫明 and 加藤 眞吾 and 古川 高子 and 福村 利光 and 神立 進 and 鈴木 和年 and 佐賀 恒夫 and 辻井 博彦},
 month = {Apr},
 note = {Poupose: To determine if Cu-62 labeled diacetyl-bis (N (4)-methylthiosemicarbazone); (Cu-62-ATSM) imaging of tumor hypoxia is associated with C-11-methionine(MET) imaging of amino acid metabolism in cervical cancer.
\nMethod: PET/CT was performed in ten patients with cervical cancer for evaluation of both tumor hypoxia using Cu-62-ATSM and amino acid metabolism using MET. Histologically confirmed eight squamous cell carcinoma, four adenocarcima, two adenosquamous carcinoma and melanoma were enrolled in this study. Distribution of Cu-62-ATSM in tumor was compared with that of MET. The two-group system was evaluated the distribution of uptake as Matched (mostly matched with each other) and Mismatched (with each other). Tumor uptake of each tracer was also analyzed semi-quantitatively by Tumor-to-Normal-Tissue-Ratio (TNR).
\nResult: Matched and Mismatched-groups were 1 case (6.7%) and 14 cases (93.3%), respectively. In Mismatched-group, Cu-62-ATSM tend to accumulate around the distal margin of high MET uptake area in the tumor. Mean TNR was 9.5 in MET and 4.0 in Cu-62-ATSM, and thus image contrast between tumor and surrounding normal tissue was higher in MET PET/CT image than Cu-62-ATSM PET/CT image.
\nConclusion: Cu-62-ATSM and MET showed different distribution in most cases of cervical cancer. Cervical cancer had a greater tendency for the uptake of MET than Cu-62-ATSM., H20年度HIMAC共同利用研究成果発表会},
 title = {子宮頸癌における重粒子線治療前後のMethionine-PETと62CuATSM-PET診断の比較研究},
 year = {2009}
}