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Comparison of Radiocurability of Human Xenograft Tumor After Irradiated With Carbon-Ion and X-ray In Nude Mice
https://repo.qst.go.jp/records/63153
https://repo.qst.go.jp/records/6315379bdefa0-ac1b-43c7-a369-8105c7da2da2
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-07-15 | |||||
| タイトル | ||||||
| タイトル | Comparison of Radiocurability of Human Xenograft Tumor After Irradiated With Carbon-Ion and X-ray In Nude Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sai, Sei
× Sai, Sei× Matsumoto, Yoshitaka× Furusawa, Yoshiya× Tsujii, Hirohiko× Okayasu, Ryuichi× 崔 星× 松本 孔貴× 古澤 佳也× 辻井 博彦× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To determine xenograft tumor radiocurability of carbon-ion (C290, 50keV/m, 6-cm SOBP) and X-ray, human colon cancer cells HCT116 were inoculated into the nude mice and were irradiated when the tumors grew to a certain size. Carbon-ion irradiation effectively suppressed tumor growth. However, the tumors re-grew after 8-week when irradiated with 15 Gy, but all the tumors were regressed and consequently eradicated without any relapse in the 12-week follow-up when irradiated with 30 Gy. In comparison, xenograft tumors were suppressed for 4-week with 30 Gy and completely eradicated with 60 Gy X-ray irradiation. The relative biological effects (RBE) value of carbon-ion relative to X-rays was 3.82. At an isodose of 30 Gy, carbon-ion irradiation predominantly induced tumor cell cavitation, fiborosis and the duct-like architecture was completely disrupted, whereas X-ray irradiation only partially destroyed tumor cells and the duct-like architecture still remained. Histopathological analysis showed that tumor-supplying vessels were markedly reduced in carbon-ion irradiated mice compared to those of X-ray irradiated mice. Immunohistochemical study demonstrated that expression of VEGF, HIF-1, -catenin and cancer stem cell marker CD133 was predominantly suppressed by carbon-ion irradiation, whereas X-ray increased the expression of these proteins. In conclusion, heavy-ion irradiation has a high radiocurability compared to conventional X-ray. The effective suppression of tumor-induced angiogenesis and disruption of cancer stem cells are considered to be one of the crucial molecular mechanisms of heavy-ion radiotherapy. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | HEAVY IONS IN THERAPY AND SPACE SYMPOSIUM 2009 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-07-12 | |||||
| 日付タイプ | Issued | |||||
