{"created":"2023-05-15T14:46:14.070651+00:00","id":63153,"links":{},"metadata":{"_buckets":{"deposit":"7ca1a67c-692f-4523-acb2-fc5e905ec263"},"_deposit":{"created_by":1,"id":"63153","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63153"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063153","sets":["10:29"]},"author_link":["623830","623835","623827","623834","623832","623833","623828","623829","623831","623826"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-07-12","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To determine xenograft tumor radiocurability of carbon-ion (C290, 50keV/m, 6-cm SOBP) and X-ray, human colon cancer cells HCT116 were inoculated into the nude mice and were irradiated when the tumors grew to a certain size. Carbon-ion irradiation effectively suppressed tumor growth. However, the tumors re-grew after 8-week when irradiated with 15 Gy, but all the tumors were regressed and consequently eradicated without any relapse in the 12-week follow-up when irradiated with 30 Gy. In comparison, xenograft tumors were suppressed for 4-week with 30 Gy and completely eradicated with 60 Gy X-ray irradiation. The relative biological effects (RBE) value of carbon-ion relative to X-rays was 3.82. At an isodose of 30 Gy, carbon-ion irradiation predominantly induced tumor cell cavitation, fiborosis and the duct-like architecture was completely disrupted, whereas X-ray irradiation only partially destroyed tumor cells and the duct-like architecture still remained. Histopathological analysis showed that tumor-supplying vessels were markedly reduced in carbon-ion irradiated mice compared to those of X-ray irradiated mice. Immunohistochemical study demonstrated that expression of VEGF, HIF-1, -catenin and cancer stem cell marker CD133 was predominantly suppressed by carbon-ion irradiation, whereas X-ray increased the expression of these proteins. In conclusion, heavy-ion irradiation has a high radiocurability compared to conventional X-ray. The effective suppression of tumor-induced angiogenesis and disruption of cancer stem cells are considered to be one of the crucial molecular mechanisms of heavy-ion radiotherapy.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"HEAVY IONS IN THERAPY AND SPACE SYMPOSIUM 2009","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sai, Sei"}],"nameIdentifiers":[{"nameIdentifier":"623826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Yoshitaka"}],"nameIdentifiers":[{"nameIdentifier":"623827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"623828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"623829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"623830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔 星","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"623831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 孔貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"623832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"623833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"623834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"623835","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Comparison of Radiocurability of Human Xenograft Tumor After Irradiated With Carbon-Ion and X-ray In Nude Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of Radiocurability of Human Xenograft Tumor After Irradiated With Carbon-Ion and X-ray In Nude Mice"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-07-15"},"publish_date":"2009-07-15","publish_status":"0","recid":"63153","relation_version_is_last":true,"title":["Comparison of Radiocurability of Human Xenograft Tumor After Irradiated With Carbon-Ion and X-ray In Nude Mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:22:36.461239+00:00"}