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胎児・成体マウスにおける放射線誘発適応応答は重粒子線にも当て嵌まるか
https://repo.qst.go.jp/records/63053
https://repo.qst.go.jp/records/63053ab18c56b-e79d-4448-b074-325cfe06cca4
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-04-17 | |||||
| タイトル | ||||||
| タイトル | 胎児・成体マウスにおける放射線誘発適応応答は重粒子線にも当て嵌まるか | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
王, 冰
× 王, 冰× 田中, 薫× Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ× 二宮, 康晴× 尚, 奕× 藤田, 和子× 笠井, 清美× 根井, 充× 王 冰× 田中 薫× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 二宮 康晴× 尚 奕× 藤田 和子× 笠井 清美× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Possible induction of adaptive response (AR) by the high LET accelerated heavy ion irradiations (HI) is being attempted both in young adult female mice and in fetal mice of C57BL/6J Jms strain, using growth delay, hematopoietic damage and reduced survival in vivo, prenatal growth delay, malformation and death in utero as endpoints. Investigations are to verify 1) if priming dose from low LET X-irradiation could induce an AR against the detrimental effects from the high challenging dose of HI, 2) if priming dose from HI could induce an AR against the high challenging dose from low LET X-irradiations, and 3) if an AR could be induced when both priming and challenging doses are from HI. Three kinds of HI are being examined: carbon, silicon and iron, with the LET values of about 15, 55, and 200 keV/micrometer, respectively. Results show, at whole body level for the first time, that 1) priming dose of low LET X-irradiations could induce AR both in vivo and in utero against the challenging dose from high LET HI, and 2) priming dose from high LET HI could induce AR against the challenging dose from low LET X-irradiations in vivo. The remaining questions that 1) if priming dose from HI could induce an AR against the challenging dose from low LET X-irradiations in utero, 2) if an AR could be induced both in vivo and in utero when both priming and challenging doses are from HI, and 3) if there is any LET dependency in AR induction at whole body level, are still to be answered by further intensive investigations. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成20年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-04-14 | |||||
| 日付タイプ | Issued | |||||
