@misc{oai:repo.qst.go.jp:00063053,
 author = {王, 冰 and 田中, 薫 and Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ and 二宮, 康晴 and 尚, 奕 and 藤田, 和子 and 笠井, 清美 and 根井, 充 and 王 冰 and 田中 薫 and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 二宮 康晴 and 尚 奕 and 藤田 和子 and 笠井 清美 and 根井 充},
 month = {Apr},
 note = {Possible induction of adaptive response (AR) by the high LET
 accelerated heavy ion irradiations (HI) is being attempted both in young
 adult female mice and in fetal mice of C57BL/6J Jms strain, using growth
 delay, hematopoietic damage and reduced survival in vivo, prenatal growth
 delay, malformation and death in utero as endpoints. Investigations are to
 verify 1) if priming dose from low LET X-irradiation could induce an AR
 against the detrimental effects from the high challenging dose of HI, 2) if
 priming dose from HI could induce an AR against the high challenging dose
 from low LET X-irradiations, and 3) if an AR could be induced when both
 priming and challenging doses are from HI. Three kinds of HI are being
 examined: carbon, silicon and iron, with the LET values of about 15, 55, and
 200 keV/micrometer, respectively. Results show, at whole body level for the
 first time, that 1) priming dose of low LET X-irradiations could induce AR
 both in vivo and in utero against the challenging dose from high LET HI, and
 2) priming dose from high LET HI could induce AR against the challenging
 dose from low LET X-irradiations in vivo. The remaining questions that 1) if
 priming dose from HI could induce an AR against the challenging dose from
 low LET X-irradiations in utero, 2) if an AR could be induced both in vivo
 and in utero when both priming and challenging doses are from HI, and 3) if
 there is any LET dependency in AR induction at whole body level, are still
 to be answered by further intensive investigations., 平成20年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究発表会},
 title = {胎児・成体マウスにおける放射線誘発適応応答は重粒子線にも当て嵌まるか},
 year = {2009}
}