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非小細胞肺癌の炭素イオン線治療前後におけるプロテオーム変化の解析
https://repo.qst.go.jp/records/63031
https://repo.qst.go.jp/records/630316208cb1c-c0bc-4f5a-a064-3b7cc34060d5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-04-03 | |||||
| タイトル | ||||||
| タイトル | 非小細胞肺癌の炭素イオン線治療前後におけるプロテオーム変化の解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
中嶋, 美緒
× 中嶋, 美緒× 馬場, 雅行× 須金, 紀雄× 宮本, 忠昭× 本村, 真理× 山田, 泰寿× 清水, 一範× 梅村, 啓史× 野村, 文夫× その他× 中嶋 美緒× 馬場 雅行× 須金 紀雄× 宮本 忠昭× 本村 真理× 山田 泰寿× 清水 一範× 野村 文夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: We aimed both prediction of tumor responses before carbon ion radiotherapy and early evaluation of that after carbon ion radiotherapy by proteome analysis for blood and urine samples from patients with non small cell lung cancer. Materials and Method: We enrolled patients with non-small cell lung cancer underwent carbon ion radiotherapy at Research Center Hospital for Charged Particle Therapy in NIRS after September, 2006. We treated each 5mu L serum samples of 16 patients (eight adenocarcinoma and eight squamous cell caricinoma) before treatment and 1 day and 1,3,6,9 months after treatment by ClinProtTM system( Bruker Daltonics company) of Matrix assisted laser disorption/ionization time-of-fight mass spectrometry (MALDI-TOF MS) and analyzed each peak spectra. Result: The significant changes of peaks were observed in all cases after the therapy. The changes of the peaks showed different patterns depending on histological subtypes. We also found the intensity of some peaks decrease with time after the therapy, especially some intensity of those peaks had already decreased in a day after the therapy. It was suggested that these peaks could become biomarkers in regard to tumor response after the therapy, for which it is difficult to be evaluated with imaging modalities after the therapy. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H19年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-04-15 | |||||
| 日付タイプ | Issued | |||||
