@misc{oai:repo.qst.go.jp:00063031,
 author = {中嶋, 美緒 and 馬場, 雅行 and 須金, 紀雄 and 宮本, 忠昭 and 本村, 真理 and 山田, 泰寿 and 清水, 一範 and 梅村, 啓史 and 野村, 文夫 and その他 and 中嶋 美緒 and 馬場 雅行 and 須金 紀雄 and 宮本 忠昭 and 本村 真理 and 山田 泰寿 and 清水 一範 and 野村 文夫},
 month = {Apr},
 note = {Purpose: We aimed both prediction of tumor responses before carbon ion radiotherapy and early evaluation of that after carbon ion radiotherapy by proteome analysis for blood and urine samples from patients with non small cell lung cancer.
Materials and Method: We enrolled patients with non-small cell lung cancer underwent carbon ion radiotherapy at Research Center Hospital for Charged Particle Therapy in NIRS after September, 2006. We treated each 5mu L serum samples of 16 patients (eight adenocarcinoma and eight squamous cell caricinoma) before treatment and 1 day and 1,3,6,9 months after treatment by ClinProtTM system( Bruker Daltonics company) of Matrix assisted laser disorption/ionization time-of-fight mass spectrometry (MALDI-TOF MS) and analyzed each peak spectra.
Result: The significant changes of peaks were observed in all cases after the therapy. The changes of the peaks showed different patterns depending on histological subtypes. We also found the intensity of some peaks decrease with time after the therapy, especially some intensity of those peaks had already decreased in a day after the therapy. It was suggested that these peaks could become biomarkers in regard to tumor response after the therapy, for which it is difficult to be evaluated with imaging modalities after the therapy., H19年度HIMAC共同利用研究成果発表会},
 title = {非小細胞肺癌の炭素イオン線治療前後におけるプロテオーム変化の解析},
 year = {2008}
}