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Radiobiology for chordoma cell line UCH1
https://repo.qst.go.jp/records/62998
https://repo.qst.go.jp/records/62998b50103eb-38d8-4f7f-84f2-045a44d8adc2
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-03-23 | |||||
| タイトル | ||||||
| タイトル | Radiobiology for chordoma cell line UCH1 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kato, Takamitsu
× Kato, Takamitsu× 加藤 宝光 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract The aim of this study is to investigate the cellular radiosensitivity of a chordoma cell line, U-CH1. U-CH1 was compared with two different cancer lines, the glioblastoma cell line U87-MG and the cervical cancer cell line HeLa, to understand their phenotypes. We analyzed cell doubling times, DNA contents, and cell cycle distributions to characterize these cell lines and determined radiosensitivities by colony formation assay. Cell doubling time for U-CH1 was 3 days, which was much longer than the other tumor cell lines. The doubling times for U87-MG and HeLa cells were 24 hours and 18 hours, respectively. U-CH1 had the most DNA content among the three cell lines and was near tetraploid. UCH-1 and U87-MG were more sensitive to x-irradiation than HeLa cells. Heavy ion particle irradiation efficiently killed all cell lines compared to x-ray exposure. Relative biological effectiveness (RBE) at 10% survival of glioblastoma and HeLa cells was about 2.5 for LET 70keV/um carbon ions and 3 for LET 200keV/um iron beams, while for U-CH1 it was 2.5 for LET 70keV/um carbon ions and 4 for LET 200keV/um iron beams. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ＮＲＩＳ エトワール ジョイントシンポジウム | |||||
| 発表年月日 | ||||||
| 日付 | 2009-03-17 | |||||
| 日付タイプ | Issued | |||||
