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マウス腫瘍モデルでの炭素イオン線およびγ線照射における腫瘍分子イメージングの解析
https://repo.qst.go.jp/records/62692
https://repo.qst.go.jp/records/626929f8c8094-d1a9-427a-9ec3-8056a0904281
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-03 | |||||
| タイトル | ||||||
| タイトル | マウス腫瘍モデルでの炭素イオン線およびγ線照射における腫瘍分子イメージングの解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
田巻, 倫明
× 田巻, 倫明× 大野, 達也× 加藤, 真吾× 吉川, 京燦× 岩川, 眞由美× 今井, 高志× 古川, 高子× 佐賀, 恒夫× 福村, 利光× 鈴木, 和年× 田巻 倫明× 大野 達也× 加藤 眞吾× 吉川 京燦× 岩川 眞由美× 今井 高志× 古川 高子× 佐賀 恒夫× 福村 利光× 鈴木 和年 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hypoxia causes various kinds of malignant transformation in tumor cells and is considered to lead to the development of radioresistance. Cu-ATSM has been proven to be a promising agent to identify hypoxic portion of tumors in PET, and studies suggest that it may predict the prognosis of radiothraoy patients. We investigated the relationship between the Cu-ATSM accumulation in tumors and the radiosensitivity in a mouse tumor model. Three pairs of mouse tumors (squamous cell carcinoma, fibrosarcoma, and adenocarcinoma) with known radiosensitivity were transplanted in synergic C3H mice, and the biodistribution of 62Cu-ATSM was studied. In the pairs of squamous cell carcinoma (NR-S1 and SCCVII) and fibrosarcoma (NFSa and #8520), which have shown different degrees of radiosensitivity, the accumulation of 62Cu-ATSM was significantly higher in the radioresistant typess pf tumors (NR-S1 and NFSa) than in the radiosensitive types (SCCVII and #8520). In the pair of adenocarcinoma (MMCa and MCa#4), which demonstrate similar degree of radiosensitivity, the accumulation of 62Cu-ATSM did not differ significantly between these two types of adenocarcinoma. These results suggest that the qualitative PET imaging using 62Cu-ATSM may be able to identify patients with radioresistant tumor types and lead to selection of candidates who may most denefit from carbon ion therapy. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H19年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-04-15 | |||||
| 日付タイプ | Issued | |||||
