{"created":"2023-05-15T14:45:53.397438+00:00","id":62692,"links":{},"metadata":{"_buckets":{"deposit":"1db140f3-277f-425c-868b-8382e35939f8"},"_deposit":{"created_by":1,"id":"62692","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62692"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062692","sets":["10:29"]},"author_link":["619285","619280","619288","619295","619286","619294","619290","619296","619283","619281","619284","619282","619289","619292","619291","619298","619287","619293","619297","619279"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-04-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hypoxia causes various kinds of malignant transformation in tumor cells and is considered to lead to the development of radioresistance. Cu-ATSM has been proven to be a promising agent to identify hypoxic portion of tumors in PET, and studies suggest that it may predict the prognosis of radiothraoy patients. We investigated the relationship between the Cu-ATSM accumulation in tumors and the radiosensitivity in a mouse tumor model. Three pairs of mouse tumors (squamous cell carcinoma, fibrosarcoma, and adenocarcinoma) with known radiosensitivity were transplanted in synergic C3H mice, and the biodistribution of 62Cu-ATSM was studied. In the pairs of squamous cell carcinoma (NR-S1 and SCCVII) and fibrosarcoma (NFSa and #8520), which have shown different degrees of radiosensitivity, the accumulation of 62Cu-ATSM was significantly higher in the radioresistant typess pf tumors (NR-S1 and NFSa) than in the radiosensitive types (SCCVII and #8520). In the pair of adenocarcinoma (MMCa and MCa#4), which demonstrate similar degree of radiosensitivity, the accumulation of 62Cu-ATSM did not differ significantly between these two types of adenocarcinoma. These results suggest that the qualitative PET imaging using 62Cu-ATSM may be able to identify patients with radioresistant tumor types and lead to selection of candidates who may most denefit from carbon ion therapy.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"H19年度HIMAC共同利用研究成果発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田巻, 倫明"}],"nameIdentifiers":[{"nameIdentifier":"619279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野, 達也"}],"nameIdentifiers":[{"nameIdentifier":"619280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 真吾"}],"nameIdentifiers":[{"nameIdentifier":"619281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉川, 京燦"}],"nameIdentifiers":[{"nameIdentifier":"619282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川, 眞由美"}],"nameIdentifiers":[{"nameIdentifier":"619283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井, 高志"}],"nameIdentifiers":[{"nameIdentifier":"619284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 高子"}],"nameIdentifiers":[{"nameIdentifier":"619285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"619286","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村, 利光"}],"nameIdentifiers":[{"nameIdentifier":"619287","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 和年"}],"nameIdentifiers":[{"nameIdentifier":"619288","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田巻 倫明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619289","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 眞吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉川 京燦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619298","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"マウス腫瘍モデルでの炭素イオン線およびγ線照射における腫瘍分子イメージングの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス腫瘍モデルでの炭素イオン線およびγ線照射における腫瘍分子イメージングの解析"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-09-03"},"publish_date":"2008-09-03","publish_status":"0","recid":"62692","relation_version_is_last":true,"title":["マウス腫瘍モデルでの炭素イオン線およびγ線照射における腫瘍分子イメージングの解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:27:52.069882+00:00"}