WEKO3
アイテム
重粒子線のRBEと治療可能比の検討；放射線抵抗性腫瘍と正常組織の比較
https://repo.qst.go.jp/records/62691
https://repo.qst.go.jp/records/62691fd1e7566-f56d-447f-857e-e9b33f273592
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-03 | |||||
| タイトル | ||||||
| タイトル | 重粒子線のRBEと治療可能比の検討；放射線抵抗性腫瘍と正常組織の比較 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
長谷川, 正俊
× 長谷川, 正俊× 浅川, 勇雄× 玉本, 哲朗× 石内, 勝吾× 大野, 達也× 桜井, 英幸× 中野, 隆史× 鈴木, 義行× 新, 雅子× 田巻, 倫明× 加藤, 真吾× 村上, 健× 長谷川 正俊× 浅川 勇雄× 玉本 哲郎× 石内 勝吾× 大野 達也× 櫻井 英幸× 中野 隆史× 鈴木 義行× 新 雅子× 田巻 倫明× 加藤 眞吾× 村上 健 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aim of this study is to investigate the radiobiological efficacy of heavy in beams by comparing RBE values of radioresistant human tumors and those of radioresistant human tumors and those of radiosensitive nomal tissues. Human brain tumors (two glioblastomas, an ependymoblastoma, and a primitive neuroectodermal tumor:ONET) were transplanted to nude mice subcutaneously, and the mice were irradiated with carbon ion beams (290MeV/u, 6cm SOBP) or 200kV X-rays, Tumors, brains, spleens, kidneys, livers, duodenums, and testes were excised 4, 6, 24 hours or 5 weeks after irradiation. They were stained with H.E., p53, Ki-67, GFAP or TUNEL, and microscopically examined to evaluate apoptosis and other histological changes. RBE values of carbon ion beams were more than 1.0, but the values varied according to the tumors, organs, and endpoints. RBE values evaluated by apoptosis were 3.0, 3.6, and 6.1 for the ependymoblastoma, the PNET, and the glioblastoma, resoectively. In contrast, RBE values for radiosensitive nomal tissues were 1.2-2.1. GFAP-positive cells in the ependymoblastoma increased following irradiation. Less histological changes were observed in normal brain tissues after carbon or X-ray irradiation. These results suggested that the heavy ion beams are more favorable for treating radioresistant tumors. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H19年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-04-15 | |||||
| 日付タイプ | Issued | |||||
