@misc{oai:repo.qst.go.jp:00062691,
 author = {長谷川, 正俊 and 浅川, 勇雄 and 玉本, 哲朗 and 石内, 勝吾 and 大野, 達也 and 桜井, 英幸 and 中野, 隆史 and 鈴木, 義行 and 新, 雅子 and 田巻, 倫明 and 加藤, 真吾 and 村上, 健 and 長谷川 正俊 and 浅川 勇雄 and 玉本 哲郎 and 石内 勝吾 and 大野 達也 and 櫻井 英幸 and 中野 隆史 and 鈴木 義行 and 新 雅子 and 田巻 倫明 and 加藤 眞吾 and 村上 健},
 month = {Apr},
 note = {The aim of this study is to investigate the radiobiological efficacy of heavy in beams by comparing RBE values of radioresistant human tumors and those of radioresistant human tumors and those of radiosensitive nomal tissues. Human brain tumors (two glioblastomas, an ependymoblastoma, and a primitive neuroectodermal tumor:ONET) were transplanted to nude mice subcutaneously, and the mice were irradiated with carbon ion beams (290MeV/u, 6cm SOBP) or 200kV X-rays, Tumors, brains, spleens, kidneys, livers, duodenums, and testes were excised 4, 6, 24 hours or 5 weeks after irradiation. They were stained with H.E., p53, Ki-67, GFAP or TUNEL, and microscopically examined to evaluate apoptosis and other histological changes. RBE values of carbon ion beams were more than 1.0, but the values varied according to the tumors, organs, and endpoints. RBE values evaluated by apoptosis were 3.0, 3.6, and 6.1 for the ependymoblastoma, the PNET, and the glioblastoma, resoectively. In contrast, RBE values for radiosensitive nomal tissues were 1.2-2.1. GFAP-positive cells in the ependymoblastoma increased following irradiation. Less histological changes were observed in normal brain tissues after carbon or X-ray irradiation. These results suggested that the heavy ion beams are more favorable for treating radioresistant tumors., H19年度HIMAC共同利用研究成果発表会},
 title = {重粒子線のRBEと治療可能比の検討；放射線抵抗性腫瘍と正常組織の比較},
 year = {2008}
}