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マウス腫瘍の重粒子線照射効果関連遺伝子群の網羅的解析
https://repo.qst.go.jp/records/62681
https://repo.qst.go.jp/records/626819faf6318-fdb6-45a0-ab2a-bf467a88836f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-08-19 | |||||
| タイトル | ||||||
| タイトル | マウス腫瘍の重粒子線照射効果関連遺伝子群の網羅的解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
岩川, 眞由美
× 岩川, 眞由美× 野尻, 和典× 田巻, 倫明× 酒井, 美奈子× 今留, 香織× 今井, 高志× 岩川 眞由美× 野尻 和典× 田巻 倫明× 酒井 美奈子× 今留 香織× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To identify molecular mechanism of effectiveness induced by carbon-ion radiotherapy, we investigated expression profiles of murine tumors, which varied its radiosensitivity to gamma irradiation, using microarrays consisting of 55K genes. Six murine tumors (squamous cell carcinoma: NR-S1, SCCVII, Fibrosarcoma: NFSa, #8520, and Mammary carcinoma: MCa#4, MMCa) were transplanted in hind legs of C3H/Henirs mice and solid tumors were irradiated with either carbon-ion beam or gamma-ray. In microarray analysis, the pairwise comparisons between pre-treatment sample and post- treatment sample at 6h, 1 day, and 3 day after irradiation in each tumor were made by Wilcoxon test. We detected several tens of genes, whose expressions were significantly changed after carbon-irradiation. These genes were ontologically categorized into cell-cycle and immune response. Furthermore, comparison of expression intensity between radiosensitive (SCC-VII) and radioresistant (NR- S1) tumors by ANOVA test revealed a candidate molecule to be related with radioresistance. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H19年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-04-15 | |||||
| 日付タイプ | Issued | |||||
