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Mapping of amyloid deposition in early- and late-onset Alzheimer's disease
https://repo.qst.go.jp/records/62673
https://repo.qst.go.jp/records/62673ccfd940a-a023-428b-884d-05edafc203cd
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-08-11 | |||||
| タイトル | ||||||
| タイトル | Mapping of amyloid deposition in early- and late-onset Alzheimer's disease | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shinoto, Hitoshi
× Shinoto, Hitoshi× 篠遠 仁 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nineteen healthy subjects (12M and 7F, 6412 y.o.), 27 patients with EOAD (12M and 15F, 625 y.o.), and 23 patients with LOAD (7M and 14F, 745 y.o.) took part in this study. AD patients were divided into subgroups according to MMSE scores; mildly (MMSE score 20-23, n=7 in EOAD and LOAD), moderately I (MMSE 16-19, n=7 in EOAD and LOAD), moderately II (MMSE 11-15, n=6 in EOAD and 7 in LOAD), and severely demented groups (MMSE 0-10, n=7 in EOAD and 0 in LOAD). [11C]MP4A-PET acquisition was a dynamic sequence of 14 PET scans over a 40-minute period. A three-compartment model was employed to yield voxel-by-voxel estimates of K1, k2, and k3 in the whole brain using the arterial input function. Group comparisons of k3 values (indices of AChE activity) in normal controls and each patient group were performed using two-sample t-test in SPM2 (uncorrected p<0.0001, cluster extent K> 50 voxels). | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | International Conference on Alzhiemer’s disease 2008 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-07-31 | |||||
| 日付タイプ | Issued | |||||
