@misc{oai:repo.qst.go.jp:00062673,
 author = {Shinoto, Hitoshi and 篠遠 仁},
 month = {Jul},
 note = {Nineteen healthy subjects (12M and 7F, 6412 y.o.), 27 patients with EOAD (12M and 15F, 625 y.o.), and 23 patients with LOAD (7M and 14F, 745 y.o.) took part in this study. AD patients were divided into subgroups according to MMSE scores; mildly (MMSE score 20-23, n=7 in EOAD and LOAD), moderately I (MMSE 16-19, n=7 in EOAD and LOAD), moderately II (MMSE 11-15, n=6 in EOAD and 7 in LOAD), and severely demented groups (MMSE 0-10, n=7 in EOAD and 0 in LOAD). [11C]MP4A-PET acquisition was a dynamic sequence of 14 PET scans over a 40-minute period. A three-compartment model was employed to yield voxel-by-voxel estimates of K1, k2, and k3 in the whole brain using the arterial input function. Group comparisons of k3 values (indices of AChE activity) in normal controls and each patient group were performed using two-sample t-test in SPM2 (uncorrected p<0.0001, cluster extent K> 50 voxels)., International Conference on Alzhiemer’s disease　2008},
 title = {Mapping of amyloid deposition in early- and late-onset Alzheimer's disease},
 year = {2008}
}