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Nanohybrids for Multimodal Molecular imaging: Synthesis, Spectral Characteristics and Applications
https://repo.qst.go.jp/records/62658
https://repo.qst.go.jp/records/62658f17a27e6-c1e5-4b13-91de-72d7d2862ab5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-08-04 | |||||
| タイトル | ||||||
| タイトル | Nanohybrids for Multimodal Molecular imaging: Synthesis, Spectral Characteristics and Applications | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhelev, Zhivko
× Zhelev, Zhivko× Bakalova-Zheleva, Rumiana× Aoki, Ichio× Obata, Takayuki× Kanno, Iwao× et.al× Ｚｈｅｌｅｖ Ｚｈｉｖｋｏ× バカロバ ルミアナ× 青木 伊知男× 小畠 隆行× 菅野 巖 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nanohybrids for Multimodal Molecular Imaging: Synthesis, Spectral Characteristics and Application Authors : Z. Zhelev, R. Bakalova, I. Aoki, K. Yoneyama, M. Obata, V. Gadjeva,* I. Kanno Molecular Imaging Center, National Institute of Radiological Sciences, NIRS, 4-9-1 Anagawa, Inage, Chiba 263-8555, Japan *Department of Chemistry and Biochemistry, Thracian University, Stara Zagora, Resume : The architecture of biocompatible nanoparticles allows a development of novel molecular probes with multimodality for simultaneous application in different imaging techniques, e.g., optical imaging, magnetic resonance imaging (MRI), positron emission tomography (PET), X-ray, electron paramagnetic resonance (EPR) imaging, etc. These probes open new trends in development of multimodal imaging instruments – the future of bioimaging. The present study describes a synthesis of several original nanohybrids for multimodal imaging. They are based on organic/inorganic-coated metal nanoparticles, dendrimers, ion chelators, paramagnetic fatty acids, and spin-labeled nitrosoureas and triazenes. The probes are functionalized with different ligands attached on their surface or incorporated into the structure. The nanohybrids are divided in two groups according to their spectral characteristics. The probes from the first group are characterized with strong photoluminescence and MRI contrast signals and could be applied simultaneously in fluorescent imaging and MRI. The probes from the second group are characterized with strong MRI and EPR signals and could be applied simultaneously in MRI and EPR imaging. The structure of some nanoparticles allows an approximate calculation of their concentration in moles, which is beneficial for dose-dependent analyses in the life science. All materials were tested for biocompatibility and applied in the imaging of molecular targets on cells and animals. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Ethe 15th International Symposium on Nanoscience and Nanotechnology E-MRS 2008Spring Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2008-05-30 | |||||
| 日付タイプ | Issued | |||||
