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Quantative analysis of dopaine D2 receptor binding in human brain using PET with a agonist redioligand[11C]MNPA
https://repo.qst.go.jp/records/62639
https://repo.qst.go.jp/records/626396bbd5367-965c-453e-9489-535046ba9fe4
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-07-22 | |||||
| タイトル | ||||||
| タイトル | Quantative analysis of dopaine D2 receptor binding in human brain using PET with a agonist redioligand[11C]MNPA | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Otsuka, Tatsui
× Otsuka, Tatsui× Ito, Hiroshi× Takahashi, Hidehiko× Takano, Harumasa× Arakawa, Ryosuke× Okumura, Masaki× Kodaka, Fumitoshi× Miyoshi, Michie× Sekine, Mizuho× Seki, Chie× Suhara, Tetsuya× Halldin, Christer× Farde, Lars× 大塚 達以× 伊藤 浩× 高橋 英彦× 高野 晴成× 荒川 亮介× 奥村 正紀× 小高 文聰× 三好 美智恵× 関根 瑞保× 関 千江× 須原 哲也× ハルディン クリスタ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Intrroduction:It has been establishied in vitro that dopamine D2 receptor could be classified into two inrweconvertible affinity states to natural agonist dopamine, the high-and low-affinity states.Dopamine D2 receotir binding in vivo has wildly been measured by PET with the use of antagonist radioligands,such as[11C]racloprode,however,the high-ans low-ahhinity states of dopamine D2 receptors can be distinguished by the antagonist radiologands.(R)-2-11CH3O-N-n-propylnorapomorphine([11C]MNPA)has recentaly been devdeloped as a potent new agonist for in vivo imaging of the high-affinity state of dopamine D2 receptors[1]. In presentstudy,the kinetics of[11C]MNPA in the without an arterial input function wewe alos validated. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neuroreceptor Mapping 2008 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-07-19 | |||||
| 日付タイプ | Issued | |||||
