@misc{oai:repo.qst.go.jp:00062639, author = {Otsuka, Tatsui and Ito, Hiroshi and Takahashi, Hidehiko and Takano, Harumasa and Arakawa, Ryosuke and Okumura, Masaki and Kodaka, Fumitoshi and Miyoshi, Michie and Sekine, Mizuho and Seki, Chie and Suhara, Tetsuya and Halldin, Christer and Farde, Lars and 大塚 達以 and 伊藤 浩 and 高橋 英彦 and 高野 晴成 and 荒川 亮介 and 奥村 正紀 and 小高 文聰 and 三好 美智恵 and 関根 瑞保 and 関 千江 and 須原 哲也 and ハルディン クリスタ}, month = {Jul}, note = {Intrroduction:It has been establishied in vitro that dopamine D2 receptor could be classified into two inrweconvertible affinity states to natural agonist dopamine, the high-and low-affinity states.Dopamine D2 receotir binding in vivo has wildly been measured by PET with the use of antagonist radioligands,such as[11C]racloprode,however,the high-ans low-ahhinity states of dopamine D2 receptors can be distinguished by the antagonist radiologands.(R)-2-11CH3O-N-n-propylnorapomorphine([11C]MNPA)has recentaly been devdeloped as a potent new agonist for in vivo imaging of the high-affinity state of dopamine D2 receptors[1]. In presentstudy,the kinetics of[11C]MNPA in the without an arterial input function wewe alos validated., Neuroreceptor Mapping 2008}, title = {Quantative analysis of dopaine D2 receptor binding in human brain using PET with a agonist redioligand[11C]MNPA}, year = {2008} }